Earn point on your loyalty program!arrow arc left

Cheap flights from Knoxville (TYS) to Buffalo (BUF)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Knoxville (TYS) to Buffalo (BUF)

How to find the cheapest flight from Knoxville (TYS) to Buffalo (BUF)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Buffalo (BUF)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Buffalo (BUF)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Knoxville to Buffalo in March , April 2026

27 Mar - 13 Apr $ 255.00
TYS
Knoxville
Allegiant Air
1 STOPS
BUF
Buffalo
BUF
Buffalo
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates
12 Mar - 13 Apr $ 280.00
TYS
Knoxville
Allegiant Air
2 STOPS
BUF
Buffalo
BUF
Buffalo
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates
28 Mar - 13 Apr $ 284.00
TYS
Knoxville
Allegiant Air
2 STOPS
BUF
Buffalo
BUF
Buffalo
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates

One-way flights to Buffalo from Knoxville

9:40 AM - 12:40 PM
United Airlines
1 Stops
4h 34m
TYS - BUF
$ 174
Kiwi
Pick dates
7:25 PM - 10:15 PM
United Airlines
1 Stops
4h 17m
TYS - BUF
$ 274
Kiwi
Pick dates
10:55 AM - 1:55 PM
United Airlines
1 Stops
5h 47m
TYS - BUF
$ 274
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to Buffalo (BUF)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Buffalo (BUF)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Buffalo (BUF)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.