Earn point on your loyalty program!arrow arc left

Cheap flights from Knoxville (TYS) to Des Moines (DSM)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Knoxville to Des Moines in August , September 2026

31 Aug - 27 Sep $ 426.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates
31 Aug - 22 Sep $ 431.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates
31 Aug - 20 Sep $ 462.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates

Last minute flights from Knoxville to Des Moines

28 Aug - 01 Sep $ 449.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates
28 Aug - 01 Sep $ 493.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates
24 Aug - 01 Sep $ 506.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates

One-way flights to Des Moines from Knoxville

6:02 PM - 7:55 PM
United Airlines
1 Stops
4h 21m
TYS - DSM
$ 319
Kiwi
Pick dates
7:00 AM - 9:00 AM
United Airlines
1 Stops
4h 26m
TYS - DSM
$ 319
Kiwi
Pick dates
1:59 PM - 3:50 PM
United Airlines
1 Stops
4h 19m
TYS - DSM
$ 366
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.