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Cheap flights from Knoxville (TYS) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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Cheap flights from Knoxville to Des Moines in April , May 2026

16 Apr - 04 May $ 260.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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16 Apr - 08 May $ 265.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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16 Apr - 15 May $ 270.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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Last minute flights from Knoxville to Des Moines

16 Apr - 01 May $ 305.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
2 STOPS
TYS
Knoxville
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16 Apr - 01 May $ 353.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
2 STOPS
TYS
Knoxville
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19 Apr - 01 May $ 386.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
2 STOPS
TYS
Knoxville
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One-way flights to Des Moines from Knoxville

6:00 AM - 11:39 AM
Allegiant Air
1 Stops
8h 46m
TYS - DSM
$ 127
Kiwi
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10:49 AM - 12:59 PM
United Airlines
1 Stops
4h 36m
TYS - DSM
$ 314
Kiwi
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5:53 PM - 9:40 PM
United Airlines
1 Stops
6h 24m
TYS - DSM
$ 314
Kiwi
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.