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Cheap flights from Knoxville (TYS) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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Cheap flights from Knoxville to Des Moines in November , December 2025

23 Nov - 06 Dec $ 325.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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28 Nov - 06 Dec $ 341.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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26 Nov - 06 Dec $ 367.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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Last minute flights from Knoxville to Des Moines

23 Nov - 30 Nov $ 452.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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26 Nov - 01 Dec $ 704.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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26 Nov - 30 Nov $ 1,166.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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One-way flights to Des Moines from Knoxville

6:45 AM - 9:06 AM
United Airlines
1 Stops
4h 57m
TYS - DSM
$ 183
Kiwi
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10:50 AM - 12:59 PM
United Airlines
1 Stops
4h 29m
TYS - DSM
$ 183
Kiwi
Pick dates
10:50 AM - 12:59 PM
United Airlines
1 Stops
4h 29m
TYS - DSM
$ 295
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.