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Cheap flights from Knoxville (TYS) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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Cheap flights from Knoxville to Des Moines in December 2025 , January 2026

24 Dec - 26 Jan $ 288.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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24 Dec - 05 Jan $ 303.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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24 Dec - 05 Jan $ 341.00
TYS
Knoxville
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
TYS
Knoxville
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Last minute flights from Knoxville to Des Moines

24 Dec - 31 Dec $ 474.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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24 Dec - 01 Jan $ 474.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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24 Dec - 31 Dec $ 797.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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One-way flights to Des Moines from Knoxville

5:35 PM - 8:10 PM
United Airlines
1 Stops
5h 5m
TYS - DSM
$ 171
Kiwi
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4:04 PM - 9:00 PM
United Airlines
1 Stops
8h 54m
TYS - DSM
$ 171
Kiwi
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10:50 AM - 1:00 PM
United Airlines
1 Stops
4h 30m
TYS - DSM
$ 387
Kiwi
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.