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Cheap flights from Knoxville (TYS) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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Cheap flights from Knoxville to Des Moines in September , October 2026

30 Sep - 07 Oct $ 712.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
30 Sep - 07 Oct $ 712.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
30 Sep - 07 Oct $ 712.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
Pick dates

One-way flights to Des Moines from Knoxville

6:03 PM - 10:00 PM
United Airlines
1 Stops
6h 32m
TYS - DSM
$ 375
Kiwi
Pick dates
6:03 PM - 7:55 PM
United Airlines
1 Stops
4h 20m
TYS - DSM
$ 377
Kiwi
Pick dates
6:03 PM - 7:59 PM
United Airlines
1 Stops
4h 24m
TYS - DSM
$ 377
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.