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Cheap flights from Knoxville (TYS) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
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Cheap flights from Knoxville to Des Moines in January , February 2026

28 Jan - 04 Feb $ 396.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
31 Jan - 07 Feb $ 396.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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28 Jan - 04 Feb $ 396.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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Last minute flights from Knoxville to Des Moines

27 Jan - 31 Jan $ 427.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
27 Jan - 31 Jan $ 427.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
27 Jan - 31 Jan $ 427.00
TYS
Knoxville
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
TYS
Knoxville
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One-way flights to Des Moines from Knoxville

2:00 PM - 8:48 PM
Allegiant Air
1 Stops
10h 7m
TYS - DSM
$ 188
Kiwi
Pick dates
11:10 AM - 1:09 PM
United Airlines
1 Stops
4h 23m
TYS - DSM
$ 329
Kiwi
Pick dates
11:10 AM - 1:09 PM
United Airlines
1 Stops
4h 23m
TYS - DSM
$ 352
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.