Earn point on your loyalty program!arrow arc left

Cheap flights from Mcallen (MFE) to Des Moines (DSM)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)

How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Mcallen to Des Moines in May , June 2026

30 May - 16 Jun $ 360.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
Pick dates
30 May - 06 Jun $ 364.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
Pick dates
30 May - 27 Jun $ 383.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
Pick dates

Last minute flights from Mcallen to Des Moines

30 May - 01 Jun $ 511.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
Pick dates
23 May - 01 Jun $ 626.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
Pick dates
27 May - 01 Jun $ 637.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
Pick dates

One-way flights to Des Moines from Mcallen

5:36 PM - 6:50 AM
Allegiant Air
1 Stops
15h 17m
MFE - DSM
$ 192
Kiwi
Pick dates
7:00 AM - 11:55 AM
United Airlines
1 Stops
7h 20m
MFE - DSM
$ 295
Kiwi
Pick dates
9:43 AM - 11:55 AM
United Airlines
1 Stops
4h 37m
MFE - DSM
$ 424
Kiwi
Pick dates

How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.