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Cheap flights from Mcallen (MFE) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)

How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
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How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
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How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
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Cheap flights from Mcallen to Des Moines in December 2025 , January 2026

19 Dec - 01 Jan $ 611.00
MFE
Mcallen
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
MFE
Mcallen
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31 Dec - 04 Jan $ 618.00
MFE
Mcallen
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
MFE
Mcallen
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31 Dec - 04 Jan $ 646.00
MFE
Mcallen
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
MFE
Mcallen
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Last minute flights from Mcallen to Des Moines

28 Dec - 01 Jan $ 924.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
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21 Dec - 01 Jan $ 980.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
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27 Dec - 01 Jan $ 985.00
MFE
Mcallen
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
1 STOPS
MFE
Mcallen
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One-way flights to Des Moines from Mcallen

2:05 PM - 5:00 PM
United Airlines
1 Stops
5h 16m
MFE - DSM
$ 160
Kiwi
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2:05 PM - 9:00 PM
United Airlines
2 Stops
9h 53m
MFE - DSM
$ 165
Kiwi
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9:45 AM - 11:55 AM
United Airlines
1 Stops
4h 34m
MFE - DSM
$ 211
Kiwi
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How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Mcallen (MFE) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.