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Cheap flights from Portland (PDX) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)

How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
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Cheap flights from Portland to Des Moines in September , October 2026

30 Sep - 07 Oct $ 521.00
PDX
Portland
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
PDX
Portland
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12 Sep - 02 Oct $ 762.00
PDX
Portland
Alaska Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
1 STOPS
PDX
Portland
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14 Sep - 02 Oct $ 803.00
PDX
Portland
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
1 STOPS
PDX
Portland
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Last minute flights from Portland to Des Moines

23 Sep - 30 Sep $ 604.00
PDX
Portland
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
PDX
Portland
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23 Sep - 30 Sep $ 604.00
PDX
Portland
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
PDX
Portland
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23 Sep - 30 Sep $ 604.00
PDX
Portland
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
PDX
Portland
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One-way flights to Des Moines from Portland

5:00 AM - 9:45 AM
United Airlines
1 Stops
5h 31m
PDX - DSM
$ 261
Kiwi
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7:18 AM - 3:55 PM
Alaska Airlines
1 Stops
8h 34m
PDX - DSM
$ 464
Kiwi
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4:07 PM - 8:48 PM
United Airlines
1 Stops
5h 26m
PDX - DSM
$ 474
Kiwi
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.