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Cheap flights from Portland (PDX) to Des Moines (DSM)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)

How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
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Cheap flights from Portland to Des Moines in April , May 2026

30 Apr - 28 May $ 317.00
PDX
Portland
Allegiant Air
1 STOPS
DSM
Des Moines
DSM
Des Moines
Allegiant Air
DIRECT
PDX
Portland
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12 Apr - 06 May $ 712.00
PDX
Portland
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
2 STOPS
PDX
Portland
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12 Apr - 06 May $ 765.00
PDX
Portland
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
1 STOPS
PDX
Portland
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Last minute flights from Portland to Des Moines

18 Apr - 30 Apr $ 576.00
PDX
Portland
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
PDX
Portland
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14 Apr - 30 Apr $ 686.00
PDX
Portland
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
PDX
Portland
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14 Apr - 30 Apr $ 686.00
PDX
Portland
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
PDX
Portland
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One-way flights to Des Moines from Portland

4:15 PM - 8:45 PM
United Airlines
1 Stops
5h 27m
PDX - DSM
$ 244
Kiwi
Pick dates
4:15 PM - 8:45 PM
United Airlines
1 Stops
5h 27m
PDX - DSM
$ 437
Kiwi
Pick dates
4:15 PM - 8:45 PM
United Airlines
1 Stops
5h 27m
PDX - DSM
$ 437
Kiwi
Pick dates

How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)

Related info for your journey
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How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Portland (PDX) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.