Earn point on your loyalty program!arrow arc left

Cheap flights from San Francisco (SFO) to Des Moines (DSM)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)

How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from San Francisco to Des Moines in May , June 2026

28 May - 27 Jun $ 383.00
SFO
San Francisco
Frontier Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
1 STOPS
SFO
San Francisco
Pick dates
24 May - 02 Jun $ 863.00
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
Pick dates
17 May - 02 Jun $ 2,512.00
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
Pick dates

Last minute flights from San Francisco to Des Moines

28 May - 01 Jun $ 454.00
SFO
San Francisco
Frontier Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
1 STOPS
SFO
San Francisco
Pick dates
24 May - 31 May $ 2,626.00
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
Pick dates
17 May - 31 May $ 4,276.00
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
Pick dates

One-way flights to Des Moines from San Francisco

11:36 AM - 3:45 PM
Allegiant Air
1 Stops
7h 8m
SFO - DSM
$ 230
Kiwi
Pick dates
5:00 AM - 9:50 AM
United Airlines
1 Stops
5h 36m
SFO - DSM
$ 284
Kiwi
Pick dates
12:50 AM - 8:47 AM
United Airlines
1 Stops
7h 32m
SFO - DSM
$ 284
Kiwi
Pick dates

How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.