Earn point on your loyalty program!arrow arc left

Cheap flights from San Francisco (SFO) to Des Moines (DSM)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)

How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from San Francisco to Des Moines in February , March 2026

26 Feb - 05 Mar $ 267.00
SFO
San Francisco
Frontier Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
1 STOPS
SFO
San Francisco
Pick dates
14 Feb - 07 Mar $ 736.00
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
1 STOPS
SFO
San Francisco
Pick dates
11 Feb - 07 Mar $ 736.00
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
1 STOPS
SFO
San Francisco
Pick dates

Last minute flights from San Francisco to Des Moines

25 Feb - 28 Feb $ 467.00
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
Pick dates
12 Feb - 28 Feb $ 682.00
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
Pick dates
13 Feb - 28 Feb $ 682.00
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
DSM
Des Moines
Alaska Airlines
1 STOPS
SFO
San Francisco
Pick dates

One-way flights to Des Moines from San Francisco

8:48 AM - 3:59 PM
Frontier Airlines
1 Stops
7h 54m
SFO - DSM
$ 109
Kiwi
Pick dates
6:15 AM - 3:49 PM
Frontier Airlines
1 Stops
10h 17m
SFO - DSM
$ 231
Kiwi
Pick dates
1:00 PM - 5:25 PM
United Airlines
1 Stops
5h 7m
SFO - DSM
$ 445
Kiwi
Pick dates

How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.