Earn point on your loyalty program!arrow arc left

Cheap flights from St Louis (STL) to Des Moines (DSM)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from St Louis (STL) to Des Moines (DSM)

How to find the cheapest flight from St Louis (STL) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from St Louis to Des Moines in August , September 2026

17 Aug - 22 Sep $ 327.00
STL
St Louis
Frontier Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
1 STOPS
STL
St Louis
Pick dates
17 Aug - 15 Sep $ 327.00
STL
St Louis
Frontier Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
1 STOPS
STL
St Louis
Pick dates
17 Aug - 29 Sep $ 344.00
STL
St Louis
Frontier Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
1 STOPS
STL
St Louis
Pick dates

Last minute flights from St Louis to Des Moines

26 Aug - 01 Sep $ 406.00
STL
St Louis
Frontier Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates
17 Aug - 01 Sep $ 455.00
STL
St Louis
Frontier Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates
17 Aug - 01 Sep $ 510.00
STL
St Louis
Frontier Airlines
2 STOPS
DSM
Des Moines
DSM
Des Moines
Frontier Airlines
1 STOPS
STL
St Louis
Pick dates

One-way flights to Des Moines from St Louis

5:30 PM - 7:55 PM
United Airlines
1 Stops
3h 53m
STL - DSM
$ 223
Kiwi
Pick dates
5:30 PM - 7:55 PM
United Airlines
1 Stops
3h 53m
STL - DSM
$ 285
Kiwi
Pick dates
5:30 PM - 7:55 PM
United Airlines
1 Stops
3h 53m
STL - DSM
$ 286
Kiwi
Pick dates

How to find the cheapest flight from St Louis (STL) to Des Moines (DSM)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Des Moines (DSM)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.