Earn point on your loyalty program!arrow arc left

Cheap flights from Des Moines (DSM) to Guayaquil (GYE)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Des Moines (DSM) to Guayaquil (GYE)

How to find the cheapest flight from Des Moines (DSM) to Guayaquil (GYE)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Guayaquil (GYE)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Guayaquil (GYE)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Des Moines to Guayaquil in November , December 2025

29 Nov - 11 Dec $ 749.00
DSM
Des Moines
Allegiant Air
2 STOPS
GYE
Guayaquil
GYE
Guayaquil
Allegiant Air
1 STOPS
DSM
Des Moines
Pick dates
29 Nov - 18 Dec $ 749.00
DSM
Des Moines
Allegiant Air
2 STOPS
GYE
Guayaquil
GYE
Guayaquil
Allegiant Air
1 STOPS
DSM
Des Moines
Pick dates
29 Nov - 11 Dec $ 789.00
DSM
Des Moines
Allegiant Air
2 STOPS
GYE
Guayaquil
GYE
Guayaquil
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates

Last minute flights from Des Moines to Guayaquil

21 Nov - 01 Dec $ 1,016.00
DSM
Des Moines
Allegiant Air
2 STOPS
GYE
Guayaquil
GYE
Guayaquil
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
29 Nov - 01 Dec $ 1,177.00
DSM
Des Moines
Allegiant Air
2 STOPS
GYE
Guayaquil
GYE
Guayaquil
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
23 Nov - 01 Dec $ 1,198.00
DSM
Des Moines
Allegiant Air
2 STOPS
GYE
Guayaquil
GYE
Guayaquil
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates

One-way flights to Guayaquil from Des Moines

8:00 AM - 3:25 PM
Copa Airlines
2 Stops
32h 42m
DSM - GYE
$ 367
Kiwi
Pick dates
10:55 AM - 9:40 PM
Copa Airlines
2 Stops
12h
DSM - GYE
$ 540
Kiwi
Pick dates
9:19 AM - 9:40 PM
Copa Airlines
2 Stops
13h 36m
DSM - GYE
$ 549
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to Guayaquil (GYE)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Guayaquil (GYE)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Guayaquil (GYE)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.