Earn point on your loyalty program!arrow arc left

Cheap flights from Des Moines (DSM) to Jacksonville (JAX)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Des Moines to Jacksonville in December 2025 , January 2026

30 Dec - 06 Jan $ 492.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
30 Dec - 06 Jan $ 492.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
30 Dec - 06 Jan $ 492.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates

Last minute flights from Des Moines to Jacksonville

23 Dec - 01 Jan $ 808.00
DSM
Des Moines
Allegiant Air
2 STOPS
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
28 Dec - 01 Jan $ 840.00
DSM
Des Moines
Allegiant Air
2 STOPS
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
22 Dec - 01 Jan $ 858.00
DSM
Des Moines
Allegiant Air
2 STOPS
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates

One-way flights to Jacksonville from Des Moines

3:00 PM - 8:18 PM
United Airlines
1 Stops
7h 30m
DSM - JAX
$ 279
Kiwi
Pick dates
1:30 PM - 5:52 PM
United Airlines
1 Stops
8h 46m
DSM - JAX
$ 279
Kiwi
Pick dates
3:17 PM - 6:00 PM
United Airlines
1 Stops
5h 15m
DSM - JAX
$ 489
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.