Earn point on your loyalty program!arrow arc left

Cheap flights from Des Moines (DSM) to Jacksonville (JAX)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Des Moines to Jacksonville in March , April 2026

31 Mar - 07 Apr $ 417.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
31 Mar - 07 Apr $ 417.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
31 Mar - 07 Apr $ 417.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates

Last minute flights from Des Moines to Jacksonville

27 Mar - 31 Mar $ 462.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
27 Mar - 31 Mar $ 462.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
27 Mar - 31 Mar $ 462.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates

One-way flights to Jacksonville from Des Moines

3:28 PM - 6:05 PM
United Airlines
1 Stops
5h 4m
DSM - JAX
$ 209
Kiwi
Pick dates
8:00 AM - 10:35 AM
United Airlines
1 Stops
5h 5m
DSM - JAX
$ 399
Kiwi
Pick dates
3:24 PM - 5:57 PM
United Airlines
1 Stops
5h
DSM - JAX
$ 489
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.