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Cheap flights from Des Moines (DSM) to Jacksonville (JAX)

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How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
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How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
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How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
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Cheap flights from Des Moines to Jacksonville in April , May 2026

30 Apr - 05 May $ 465.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
30 Apr - 05 May $ 465.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
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28 Apr - 01 May $ 489.00
DSM
Des Moines
United Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
United Airlines
1 STOPS
DSM
Des Moines
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Last minute flights from Des Moines to Jacksonville

26 Apr - 01 May $ 451.00
DSM
Des Moines
Frontier Airlines
2 STOPS
JAX
Jacksonville
JAX
Jacksonville
Frontier Airlines
2 STOPS
DSM
Des Moines
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17 Apr - 01 May $ 494.00
DSM
Des Moines
Frontier Airlines
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
Frontier Airlines
2 STOPS
DSM
Des Moines
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17 Apr - 01 May $ 527.00
DSM
Des Moines
Allegiant Air
1 STOPS
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
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One-way flights to Jacksonville from Des Moines

8:04 AM - 10:36 AM
United Airlines
1 Stops
5h 9m
DSM - JAX
$ 221
Kiwi
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1:10 PM - 4:00 PM
United Airlines
1 Stops
5h 24m
DSM - JAX
$ 416
Kiwi
Pick dates
8:04 AM - 10:36 AM
United Airlines
1 Stops
5h 4m
DSM - JAX
$ 419
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

Related info for your journey
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How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.