Earn point on your loyalty program!arrow arc left

Cheap flights from Des Moines (DSM) to Jacksonville (JAX)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Des Moines to Jacksonville in November , December 2025

29 Nov - 11 Dec $ 270.00
DSM
Des Moines
Allegiant Air
DIRECT
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
25 Nov - 11 Dec $ 275.00
DSM
Des Moines
Allegiant Air
DIRECT
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
29 Nov - 14 Dec $ 278.00
DSM
Des Moines
Allegiant Air
DIRECT
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates

Last minute flights from Des Moines to Jacksonville

29 Nov - 01 Dec $ 398.00
DSM
Des Moines
Allegiant Air
DIRECT
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
25 Nov - 01 Dec $ 405.00
DSM
Des Moines
Allegiant Air
DIRECT
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
29 Nov - 30 Nov $ 565.00
DSM
Des Moines
Allegiant Air
DIRECT
JAX
Jacksonville
JAX
Jacksonville
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates

One-way flights to Jacksonville from Des Moines

7:30 AM - 7:30 AM
Allegiant Air
0 Stops
2h 43m
DSM - JAX
$ 49
Kiwi
Pick dates
7:00 AM - 7:00 AM
Allegiant Air
0 Stops
2h 43m
DSM - JAX
$ 49
Kiwi
Pick dates
2:43 PM - 2:43 PM
Allegiant Air
0 Stops
2h 43m
DSM - JAX
$ 76
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to Jacksonville (JAX)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.