Earn point on your loyalty program!arrow arc left

Cheap flights from Knoxville (TYS) to San Antonio (SAT)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Knoxville (TYS) to San Antonio (SAT)

How to find the cheapest flight from Knoxville (TYS) to San Antonio (SAT)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Antonio (SAT)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Antonio (SAT)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Knoxville to San Antonio in April , May 2026

30 Apr - 10 May $ 484.00
TYS
Knoxville
United Airlines
1 STOPS
SAT
San Antonio
SAT
San Antonio
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
30 Apr - 10 May $ 484.00
TYS
Knoxville
United Airlines
1 STOPS
SAT
San Antonio
SAT
San Antonio
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
30 Apr - 10 May $ 484.00
TYS
Knoxville
United Airlines
1 STOPS
SAT
San Antonio
SAT
San Antonio
United Airlines
1 STOPS
TYS
Knoxville
Pick dates

Last minute flights from Knoxville to San Antonio

24 Apr - 30 Apr $ 604.00
TYS
Knoxville
United Airlines
1 STOPS
SAT
San Antonio
SAT
San Antonio
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
24 Apr - 30 Apr $ 604.00
TYS
Knoxville
United Airlines
1 STOPS
SAT
San Antonio
SAT
San Antonio
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
24 Apr - 30 Apr $ 777.00
TYS
Knoxville
United Airlines
1 STOPS
SAT
San Antonio
SAT
San Antonio
United Airlines
1 STOPS
TYS
Knoxville
Pick dates

One-way flights to San Antonio from Knoxville

11:25 AM - 2:32 PM
United Airlines
1 Stops
5h 21m
TYS - SAT
$ 235
Kiwi
Pick dates
5:15 PM - 9:53 PM
United Airlines
1 Stops
6h 44m
TYS - SAT
$ 235
Kiwi
Pick dates
7:05 AM - 9:43 AM
United Airlines
1 Stops
4h 45m
TYS - SAT
$ 254
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to San Antonio (SAT)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Antonio (SAT)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Antonio (SAT)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.