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Cheap flights from Des Moines (DSM) to San Diego (SAN)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)

How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
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Cheap flights from Des Moines to San Diego in January , February 2026

29 Jan - 20 Feb $ 220.00
DSM
Des Moines
Frontier Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Frontier Airlines
1 STOPS
DSM
Des Moines
Pick dates
21 Jan - 10 Feb $ 613.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
2 STOPS
DSM
Des Moines
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13 Jan - 14 Feb $ 747.00
DSM
Des Moines
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
DSM
Des Moines
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Last minute flights from Des Moines to San Diego

29 Jan - 01 Feb $ 371.00
DSM
Des Moines
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
2 STOPS
DSM
Des Moines
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29 Jan - 01 Feb $ 412.00
DSM
Des Moines
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
3 STOPS
DSM
Des Moines
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22 Jan - 01 Feb $ 417.00
DSM
Des Moines
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
2 STOPS
DSM
Des Moines
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One-way flights to San Diego from Des Moines

8:30 AM - 12:35 PM
Frontier Airlines
1 Stops
7h 31m
DSM - SAN
$ 163
Kiwi
Pick dates
5:09 PM - 7:10 PM
United Airlines
1 Stops
5h 33m
DSM - SAN
$ 416
Kiwi
Pick dates
1:35 PM - 3:56 PM
United Airlines
1 Stops
5h 53m
DSM - SAN
$ 416
Kiwi
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)

Related info for your journey
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.