Earn point on your loyalty program!arrow arc left

Cheap flights from Des Moines (DSM) to San Diego (SAN)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)

How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Des Moines to San Diego in April , May 2026

27 Apr - 20 May $ 244.00
DSM
Des Moines
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
1 STOPS
DSM
Des Moines
Pick dates
14 Apr - 06 May $ 684.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
2 STOPS
DSM
Des Moines
Pick dates
06 Apr - 05 May $ 860.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
1 STOPS
DSM
Des Moines
Pick dates

Last minute flights from Des Moines to San Diego

27 Apr - 30 Apr $ 459.00
DSM
Des Moines
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
14 Apr - 30 Apr $ 760.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
1 STOPS
DSM
Des Moines
Pick dates
05 Apr - 30 Apr $ 954.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
1 STOPS
DSM
Des Moines
Pick dates

One-way flights to San Diego from Des Moines

2:04 PM - 10:29 PM
Frontier Airlines
1 Stops
11h 55m
DSM - SAN
$ 151
Kiwi
Pick dates
1:32 PM - 3:45 PM
United Airlines
1 Stops
5h 44m
DSM - SAN
$ 438
Kiwi
Pick dates
1:32 PM - 3:45 PM
United Airlines
1 Stops
5h 44m
DSM - SAN
$ 439
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.