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Cheap flights from Des Moines (DSM) to San Diego (SAN)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)

How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
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Cheap flights from Des Moines to San Diego in December 2025 , January 2026

30 Dec - 12 Jan $ 483.00
DSM
Des Moines
Frontier Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Frontier Airlines
1 STOPS
DSM
Des Moines
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21 Dec - 01 Jan $ 886.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
1 STOPS
DSM
Des Moines
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18 Dec - 05 Jan $ 960.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
1 STOPS
DSM
Des Moines
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Last minute flights from Des Moines to San Diego

22 Dec - 02 Jan $ 663.00
DSM
Des Moines
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
3 STOPS
DSM
Des Moines
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30 Dec - 02 Jan $ 763.00
DSM
Des Moines
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
3 STOPS
DSM
Des Moines
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23 Dec - 02 Jan $ 787.00
DSM
Des Moines
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
3 STOPS
DSM
Des Moines
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One-way flights to San Diego from Des Moines

5:06 PM - 7:15 PM
United Airlines
1 Stops
5h 41m
DSM - SAN
$ 248
Kiwi
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5:30 AM - 8:05 AM
United Airlines
1 Stops
6h 10m
DSM - SAN
$ 248
Kiwi
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5:15 PM - 7:15 PM
United Airlines
1 Stops
5h 30m
DSM - SAN
$ 556
Kiwi
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)

Related info for your journey
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How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.