Earn point on your loyalty program!arrow arc left

Cheap flights from Knoxville (TYS) to San Diego (SAN)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)

How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Knoxville to San Diego in May , June 2026

27 May - 02 Jun $ 519.00
TYS
Knoxville
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
27 May - 02 Jun $ 519.00
TYS
Knoxville
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
21 May - 03 Jun $ 720.00
TYS
Knoxville
Alaska Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
1 STOPS
TYS
Knoxville
Pick dates

Last minute flights from Knoxville to San Diego

29 May - 31 May $ 580.00
TYS
Knoxville
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
23 May - 31 May $ 730.00
TYS
Knoxville
Alaska Airlines
2 STOPS
SAN
San Diego
SAN
San Diego
Alaska Airlines
1 STOPS
TYS
Knoxville
Pick dates
22 May - 31 May $ 813.00
TYS
Knoxville
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
TYS
Knoxville
Pick dates

One-way flights to San Diego from Knoxville

3:25 PM - 6:29 PM
United Airlines
1 Stops
7h 25m
TYS - SAN
$ 220
Kiwi
Pick dates
6:30 AM - 8:46 AM
United Airlines
1 Stops
7h 51m
TYS - SAN
$ 300
Kiwi
Pick dates
7:15 AM - 9:30 AM
United Airlines
1 Stops
6h 36m
TYS - SAN
$ 390
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.