Earn point on your loyalty program!arrow arc left

Cheap flights from Knoxville (TYS) to San Diego (SAN)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)

How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Knoxville to San Diego in January , February 2026

26 Jan - 20 Feb $ 229.00
TYS
Knoxville
Frontier Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Frontier Airlines
1 STOPS
TYS
Knoxville
Pick dates
26 Jan - 27 Feb $ 229.00
TYS
Knoxville
Frontier Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
Frontier Airlines
1 STOPS
TYS
Knoxville
Pick dates
26 Jan - 26 Feb $ 239.00
TYS
Knoxville
Allegiant Air
1 STOPS
SAN
San Diego
SAN
San Diego
Allegiant Air
1 STOPS
TYS
Knoxville
Pick dates

Last minute flights from Knoxville to San Diego

20 Jan - 31 Jan $ 511.00
TYS
Knoxville
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
20 Jan - 31 Jan $ 511.00
TYS
Knoxville
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
20 Jan - 31 Jan $ 511.00
TYS
Knoxville
United Airlines
1 STOPS
SAN
San Diego
SAN
San Diego
United Airlines
1 STOPS
TYS
Knoxville
Pick dates

One-way flights to San Diego from Knoxville

4:30 PM - 10:29 PM
Frontier Airlines
1 Stops
10h 38m
TYS - SAN
$ 115
Kiwi
Pick dates
4:41 PM - 9:30 PM
Alaska Airlines
1 Stops
9h 9m
TYS - SAN
$ 280
Kiwi
Pick dates
6:59 AM - 9:30 AM
United Airlines
1 Stops
7h 6m
TYS - SAN
$ 380
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to San Diego (SAN)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.