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Cheap flights from Des Moines (DSM) to San Francisco (SFO)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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Cheap flights from Des Moines to San Francisco in June , July 2026

26 Jun - 22 Jul $ 311.00
DSM
Des Moines
Allegiant Air
1 STOPS
SFO
San Francisco
SFO
San Francisco
Allegiant Air
1 STOPS
DSM
Des Moines
Pick dates
23 Jun - 08 Jul $ 868.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
Pick dates
20 Jun - 09 Jul $ 1,283.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
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Last minute flights from Des Moines to San Francisco

26 Jun - 01 Jul $ 466.00
DSM
Des Moines
Allegiant Air
1 STOPS
SFO
San Francisco
SFO
San Francisco
Allegiant Air
1 STOPS
DSM
Des Moines
Pick dates
16 Jun - 30 Jun $ 856.00
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
16 Jun - 30 Jun $ 856.00
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
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One-way flights to San Francisco from Des Moines

5:50 AM - 7:40 AM
United Airlines
1 Stops
5h 28m
DSM - SFO
$ 248
Kiwi
Pick dates
5:50 AM - 7:40 AM
United Airlines
1 Stops
5h 28m
DSM - SFO
$ 489
Kiwi
Pick dates
11:34 AM - 1:25 PM
United Airlines
1 Stops
5h 35m
DSM - SFO
$ 489
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

Related info for your journey
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.