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Cheap flights from Des Moines (DSM) to San Francisco (SFO)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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Cheap flights from Des Moines to San Francisco in April , May 2026

20 Apr - 20 May $ 273.00
DSM
Des Moines
Allegiant Air
1 STOPS
SFO
San Francisco
SFO
San Francisco
Allegiant Air
1 STOPS
DSM
Des Moines
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15 Apr - 09 May $ 848.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
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16 Apr - 10 May $ 2,847.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
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Last minute flights from Des Moines to San Francisco

20 Apr - 01 May $ 359.00
DSM
Des Moines
Frontier Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
Frontier Airlines
2 STOPS
DSM
Des Moines
Pick dates
15 Apr - 30 Apr $ 1,164.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
Pick dates
16 Apr - 30 Apr $ 1,395.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
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One-way flights to San Francisco from Des Moines

10:00 AM - 6:11 PM
Frontier Airlines
1 Stops
11h 50m
DSM - SFO
$ 191
Kiwi
Pick dates
1:10 PM - 6:20 PM
United Airlines
1 Stops
10h 10m
DSM - SFO
$ 467
Kiwi
Pick dates
5:17 PM - 7:15 PM
United Airlines
1 Stops
5h 50m
DSM - SFO
$ 473
Kiwi
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

Related info for your journey
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.