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Cheap flights from Des Moines (DSM) to San Francisco (SFO)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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Cheap flights from Des Moines to San Francisco in December 2025 , January 2026

31 Dec - 12 Jan $ 469.00
DSM
Des Moines
Frontier Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
Frontier Airlines
1 STOPS
DSM
Des Moines
Pick dates
18 Dec - 07 Jan $ 777.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
Pick dates
18 Dec - 06 Jan $ 908.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
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Last minute flights from Des Moines to San Francisco

24 Dec - 31 Dec $ 574.00
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
24 Dec - 31 Dec $ 578.00
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
24 Dec - 31 Dec $ 616.00
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
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One-way flights to San Francisco from Des Moines

5:30 AM - 7:47 AM
United Airlines
1 Stops
6h 13m
DSM - SFO
$ 257
Kiwi
Pick dates
5:30 AM - 9:52 AM
United Airlines
1 Stops
8h 17m
DSM - SFO
$ 300
Kiwi
Pick dates
5:30 AM - 7:47 AM
United Airlines
1 Stops
6h 13m
DSM - SFO
$ 370
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

Related info for your journey
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.