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Cheap flights from Des Moines (DSM) to San Francisco (SFO)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
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Cheap flights from Des Moines to San Francisco in May , June 2026

29 May - 01 Jul $ 404.00
DSM
Des Moines
Allegiant Air
1 STOPS
SFO
San Francisco
SFO
San Francisco
Allegiant Air
1 STOPS
DSM
Des Moines
Pick dates
27 May - 06 Jun $ 978.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
Pick dates
27 May - 06 Jun $ 2,636.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
1 STOPS
DSM
Des Moines
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Last minute flights from Des Moines to San Francisco

29 May - 01 Jun $ 541.00
DSM
Des Moines
Allegiant Air
1 STOPS
SFO
San Francisco
SFO
San Francisco
Allegiant Air
1 STOPS
DSM
Des Moines
Pick dates
29 May - 31 May $ 769.00
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
Pick dates
27 May - 31 May $ 1,180.00
DSM
Des Moines
Alaska Airlines
2 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
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One-way flights to San Francisco from Des Moines

5:50 AM - 7:40 AM
United Airlines
1 Stops
5h 28m
DSM - SFO
$ 282
Kiwi
Pick dates
8:00 AM - 10:30 AM
United Airlines
1 Stops
7h 15m
DSM - SFO
$ 282
Kiwi
Pick dates
5:50 AM - 7:40 AM
United Airlines
1 Stops
5h 28m
DSM - SFO
$ 324
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

Related info for your journey
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How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.