Earn point on your loyalty program!arrow arc left

Cheap flights from Des Moines (DSM) to San Francisco (SFO)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Des Moines to San Francisco in October , November 2026

26 Oct - 16 Nov $ 357.00
DSM
Des Moines
Frontier Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
Frontier Airlines
1 STOPS
DSM
Des Moines
Pick dates
30 Oct - 09 Nov $ 677.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
Pick dates
30 Oct - 06 Nov $ 2,050.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
Pick dates

Last minute flights from Des Moines to San Francisco

26 Oct - 01 Nov $ 585.00
DSM
Des Moines
Allegiant Air
1 STOPS
SFO
San Francisco
SFO
San Francisco
Allegiant Air
2 STOPS
DSM
Des Moines
Pick dates
30 Oct - 31 Oct $ 854.00
DSM
Des Moines
Alaska Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
Alaska Airlines
2 STOPS
DSM
Des Moines
Pick dates
25 Oct - 31 Oct $ 1,140.00
DSM
Des Moines
United Airlines
1 STOPS
SFO
San Francisco
SFO
San Francisco
United Airlines
1 STOPS
DSM
Des Moines
Pick dates

One-way flights to San Francisco from Des Moines

9:11 PM - 6:30 AM
Frontier Airlines
1 Stops
13h 8m
DSM - SFO
$ 225
Kiwi
Pick dates
8:30 PM - 10:29 PM
Frontier Airlines
1 Stops
5h 50m
DSM - SFO
$ 298
Kiwi
Pick dates
1:27 PM - 3:37 PM
United Airlines
1 Stops
5h 57m
DSM - SFO
$ 524
Kiwi
Pick dates

How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Des Moines (DSM) to San Francisco (SFO)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.