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Cheap flights from Charleston (CHS) to Santiago (SCL)

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0 Children (2~11)
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How to find the cheapest flight from Charleston (CHS) to Santiago (SCL)

How to find the cheapest flight from Charleston (CHS) to Santiago (SCL)
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How to find the cheapest flight from Charleston (CHS) to Santiago (SCL)
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How to find the cheapest flight from Charleston (CHS) to Santiago (SCL)
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Cheap flights from Charleston to Santiago in December 2025 , January 2026

25 Dec - 29 Jan $ 655.00
CHS
Charleston
Spirit Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Spirit Airlines
2 STOPS
CHS
Charleston
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25 Dec - 26 Jan $ 660.00
CHS
Charleston
Spirit Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Spirit Airlines
2 STOPS
CHS
Charleston
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29 Dec - 16 Jan $ 809.00
CHS
Charleston
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
CHS
Charleston
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Last minute flights from Charleston to Santiago

24 Dec - 01 Jan $ 781.00
CHS
Charleston
United Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
2 STOPS
CHS
Charleston
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24 Dec - 01 Jan $ 814.00
CHS
Charleston
United Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
CHS
Charleston
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23 Dec - 01 Jan $ 1,038.00
CHS
Charleston
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
CHS
Charleston
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One-way flights to Santiago from Charleston

10:18 PM - 9:28 PM
Copa Airlines
2 Stops
29h 43m
CHS - SCL
$ 319
Kiwi
Pick dates
5:00 PM - 8:45 PM
United Airlines
1 Stops
13h 50m
CHS - SCL
$ 583
Kiwi
Pick dates
5:00 PM - 8:45 PM
United Airlines
1 Stops
13h 50m
CHS - SCL
$ 800
Kiwi
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How to find the cheapest flight from Charleston (CHS) to Santiago (SCL)

Related info for your journey
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How to find the cheapest flight from Charleston (CHS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Charleston (CHS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.