Earn point on your loyalty program!arrow arc left

Cheap flights from Chicago (CHI) to Santiago (SCL)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)

How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Chicago to Santiago in November , December 2025

29 Nov - 05 Dec $ 719.00
CHI
Chicago
Spirit Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
Spirit Airlines
1 STOPS
CHI
Chicago
Pick dates
30 Nov - 07 Dec $ 740.00
CHI
Chicago
Avianca
1 STOPS
SCL
Santiago
SCL
Santiago
Avianca
1 STOPS
CHI
Chicago
Pick dates
30 Nov - 11 Dec $ 1,185.00
CHI
Chicago
LATAM Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
LATAM Airlines
1 STOPS
CHI
Chicago
Pick dates

Last minute flights from Chicago to Santiago

26 Nov - 01 Dec $ 832.00
CHI
Chicago
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
CHI
Chicago
Pick dates
26 Nov - 01 Dec $ 1,046.00
CHI
Chicago
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
CHI
Chicago
Pick dates
23 Nov - 01 Dec $ 1,144.00
CHI
Chicago
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
CHI
Chicago
Pick dates

One-way flights to Santiago from Chicago

10:20 PM - 7:15 AM
Avianca
1 Stops
14h
CHI - SCL
$ 399
Kiwi
Pick dates
10:20 PM - 7:15 AM
Avianca
1 Stops
14h
CHI - SCL
$ 407
Kiwi
Pick dates
4:26 PM - 8:35 PM
LATAM Airlines
1 Stops
12h 14m
CHI - SCL
$ 678
Kiwi
Pick dates

How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.