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Cheap flights from Chicago (CHI) to Santiago (SCL)

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0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)

How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
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How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
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How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
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Cheap flights from Chicago to Santiago in March , April 2026

31 Mar - 13 Apr $ 517.00
CHI
Chicago
Copa Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
Copa Airlines
1 STOPS
CHI
Chicago
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30 Mar - 13 Apr $ 537.00
CHI
Chicago
Copa Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
Copa Airlines
1 STOPS
CHI
Chicago
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10 Mar - 04 Apr $ 1,044.00
CHI
Chicago
LATAM Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
LATAM Airlines
1 STOPS
CHI
Chicago
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Last minute flights from Chicago to Santiago

24 Mar - 01 Apr $ 601.00
CHI
Chicago
Avianca
1 STOPS
SCL
Santiago
SCL
Santiago
Avianca
1 STOPS
CHI
Chicago
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10 Mar - 01 Apr $ 844.00
CHI
Chicago
Avianca
1 STOPS
SCL
Santiago
SCL
Santiago
Avianca
1 STOPS
CHI
Chicago
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10 Mar - 01 Apr $ 1,295.00
CHI
Chicago
LATAM Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
LATAM Airlines
1 STOPS
CHI
Chicago
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One-way flights to Santiago from Chicago

3:28 PM - 9:28 PM
Copa Airlines
1 Stops
12h 35m
CHI - SCL
$ 243
Kiwi
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12:45 PM - 8:45 PM
United Airlines
1 Stops
17h 5m
CHI - SCL
$ 382
Kiwi
Pick dates
3:22 PM - 9:28 PM
Copa Airlines
1 Stops
12h 38m
CHI - SCL
$ 481
Kiwi
Pick dates

How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)

Related info for your journey
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How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Chicago (CHI) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.