Earn point on your loyalty program!arrow arc left

Cheap flights from Columbus (CMH) to Santiago (SCL)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Columbus (CMH) to Santiago (SCL)

How to find the cheapest flight from Columbus (CMH) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Columbus (CMH) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Columbus (CMH) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Columbus to Santiago in April , May 2026

27 Apr - 11 May $ 779.00
CMH
Columbus
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
CMH
Columbus
Pick dates
27 Apr - 07 May $ 792.00
CMH
Columbus
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
CMH
Columbus
Pick dates
26 Apr - 08 May $ 795.00
CMH
Columbus
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
2 STOPS
CMH
Columbus
Pick dates

Last minute flights from Columbus to Santiago

26 Apr - 01 May $ 810.00
CMH
Columbus
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
3 STOPS
CMH
Columbus
Pick dates
20 Apr - 01 May $ 850.00
CMH
Columbus
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
3 STOPS
CMH
Columbus
Pick dates
26 Apr - 01 May $ 893.00
CMH
Columbus
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
3 STOPS
CMH
Columbus
Pick dates

One-way flights to Santiago from Columbus

11:03 AM - 7:25 PM
Copa Airlines
2 Stops
15h 57m
CMH - SCL
$ 416
Kiwi
Pick dates
7:40 PM - 4:20 PM
Avianca
2 Stops
27h 40m
CMH - SCL
$ 668
Kiwi
Pick dates
5:00 PM - 10:10 PM
LATAM Airlines
1 Stops
14h 15m
CMH - SCL
$ 713
Kiwi
Pick dates

How to find the cheapest flight from Columbus (CMH) to Santiago (SCL)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Columbus (CMH) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Columbus (CMH) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.