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Cheap flights from Detroit (DTW) to Santiago (SCL)

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0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Detroit (DTW) to Santiago (SCL)

How to find the cheapest flight from Detroit (DTW) to Santiago (SCL)
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How to find the cheapest flight from Detroit (DTW) to Santiago (SCL)
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How to find the cheapest flight from Detroit (DTW) to Santiago (SCL)
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Cheap flights from Detroit to Santiago in December 2025 , January 2026

31 Dec - 29 Jan $ 654.00
DTW
Detroit
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
DTW
Detroit
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31 Dec - 29 Jan $ 656.00
DTW
Detroit
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
DTW
Detroit
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31 Dec - 29 Jan $ 684.00
DTW
Detroit
Spirit Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Spirit Airlines
2 STOPS
DTW
Detroit
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Last minute flights from Detroit to Santiago

29 Dec - 31 Dec $ 1,058.00
DTW
Detroit
Spirit Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
Spirit Airlines
3 STOPS
DTW
Detroit
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23 Dec - 01 Jan $ 1,207.00
DTW
Detroit
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
DTW
Detroit
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22 Dec - 01 Jan $ 2,189.00
DTW
Detroit
LATAM Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
LATAM Airlines
2 STOPS
DTW
Detroit
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One-way flights to Santiago from Detroit

10:12 AM - 6:35 PM
LATAM Airlines
2 Stops
17h 58m
DTW - SCL
$ 313
Kiwi
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10:12 AM - 9:28 PM
Copa Airlines
2 Stops
17h 49m
DTW - SCL
$ 315
Kiwi
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4:30 PM - 8:45 PM
United Airlines
1 Stops
14h 20m
DTW - SCL
$ 680
Kiwi
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How to find the cheapest flight from Detroit (DTW) to Santiago (SCL)

Related info for your journey
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How to find the cheapest flight from Detroit (DTW) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Detroit (DTW) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.