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Cheap flights from Houston (HOU) to Santiago (SCL)

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1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Houston (HOU) to Santiago (SCL)

How to find the cheapest flight from Houston (HOU) to Santiago (SCL)
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How to find the cheapest flight from Houston (HOU) to Santiago (SCL)
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How to find the cheapest flight from Houston (HOU) to Santiago (SCL)
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Cheap flights from Houston to Santiago in December 2025 , January 2026

31 Dec - 27 Jan $ 586.00
HOU
Houston
Spirit Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Spirit Airlines
2 STOPS
HOU
Houston
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25 Dec - 08 Jan $ 1,349.00
HOU
Houston
Avianca
2 STOPS
SCL
Santiago
SCL
Santiago
Avianca
2 STOPS
HOU
Houston
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24 Dec - 06 Jan $ 1,501.00
HOU
Houston
Avianca
2 STOPS
SCL
Santiago
SCL
Santiago
Avianca
2 STOPS
HOU
Houston
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Last minute flights from Houston to Santiago

27 Dec - 31 Dec $ 959.00
HOU
Houston
Spirit Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Spirit Airlines
2 STOPS
HOU
Houston
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24 Dec - 31 Dec $ 1,080.00
HOU
Houston
Avianca
2 STOPS
SCL
Santiago
SCL
Santiago
Avianca
2 STOPS
HOU
Houston
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24 Dec - 31 Dec $ 2,328.00
HOU
Houston
United Airlines
DIRECT
SCL
Santiago
SCL
Santiago
United Airlines
DIRECT
HOU
Houston
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One-way flights to Santiago from Houston

5:46 AM - 9:35 PM
Avianca
2 Stops
20h 44m
HOU - SCL
$ 302
Kiwi
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4:35 PM - 7:15 AM
Avianca
2 Stops
19h 45m
HOU - SCL
$ 494
Kiwi
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8:45 PM - 8:45 PM
United Airlines
0 Stops
9h 5m
HOU - SCL
$ 1,299
Kiwi
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How to find the cheapest flight from Houston (HOU) to Santiago (SCL)

Related info for your journey
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How to find the cheapest flight from Houston (HOU) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Houston (HOU) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.