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Cheap flights from Knoxville (TYS) to Santiago (SCL)

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0 Children (2~11)
0 Infants (0~2)
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How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)

How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
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How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
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How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
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Cheap flights from Knoxville to Santiago in December 2025 , January 2026

31 Dec - 24 Jan $ 673.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
2 STOPS
TYS
Knoxville
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31 Dec - 24 Jan $ 684.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
2 STOPS
TYS
Knoxville
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31 Dec - 22 Jan $ 712.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
2 STOPS
TYS
Knoxville
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Last minute flights from Knoxville to Santiago

29 Dec - 01 Jan $ 1,009.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
2 STOPS
TYS
Knoxville
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29 Dec - 01 Jan $ 1,039.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
2 STOPS
TYS
Knoxville
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30 Dec - 01 Jan $ 1,090.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
2 STOPS
TYS
Knoxville
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One-way flights to Santiago from Knoxville

12:01 PM - 8:29 PM
LATAM Airlines
2 Stops
17h 39m
TYS - SCL
$ 306
Kiwi
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6:45 AM - 8:45 PM
United Airlines
2 Stops
24h 5m
TYS - SCL
$ 608
Kiwi
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5:15 PM - 8:45 PM
United Airlines
1 Stops
13h 35m
TYS - SCL
$ 1,945
Kiwi
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How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)

Related info for your journey
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How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.