Earn point on your loyalty program!arrow arc left

Cheap flights from Knoxville (TYS) to Santiago (SCL)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)

How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Knoxville to Santiago in November , December 2025

26 Nov - 04 Dec $ 768.00
TYS
Knoxville
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
27 Nov - 03 Dec $ 768.00
TYS
Knoxville
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
1 STOPS
TYS
Knoxville
Pick dates
26 Nov - 04 Dec $ 773.00
TYS
Knoxville
United Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
United Airlines
2 STOPS
TYS
Knoxville
Pick dates

Last minute flights from Knoxville to Santiago

27 Nov - 01 Dec $ 1,057.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
3 STOPS
TYS
Knoxville
Pick dates
27 Nov - 01 Dec $ 1,072.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
3 STOPS
TYS
Knoxville
Pick dates
25 Nov - 01 Dec $ 1,098.00
TYS
Knoxville
Allegiant Air
2 STOPS
SCL
Santiago
SCL
Santiago
Allegiant Air
3 STOPS
TYS
Knoxville
Pick dates

One-way flights to Santiago from Knoxville

9:00 AM - 7:12 PM
Arajet
2 Stops
17h
TYS - SCL
$ 410
Kiwi
Pick dates
4:37 PM - 8:45 PM
United Airlines
1 Stops
14h 13m
TYS - SCL
$ 684
Kiwi
Pick dates
10:50 AM - 8:45 PM
United Airlines
2 Stops
20h
TYS - SCL
$ 684
Kiwi
Pick dates

How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Knoxville (TYS) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.