Earn point on your loyalty program!arrow arc left

Cheap flights from Portland (PDX) to Santiago (SCL)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from Portland (PDX) to Santiago (SCL)

How to find the cheapest flight from Portland (PDX) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Portland (PDX) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Portland (PDX) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from Portland to Santiago in March , April 2026

28 Mar - 16 Apr $ 801.00
PDX
Portland
Alaska Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Alaska Airlines
1 STOPS
PDX
Portland
Pick dates
28 Mar - 07 Apr $ 801.00
PDX
Portland
Alaska Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Alaska Airlines
1 STOPS
PDX
Portland
Pick dates
30 Mar - 07 Apr $ 801.00
PDX
Portland
Alaska Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Alaska Airlines
1 STOPS
PDX
Portland
Pick dates

Last minute flights from Portland to Santiago

30 Mar - 01 Apr $ 846.00
PDX
Portland
Hawaiian Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Hawaiian Airlines
1 STOPS
PDX
Portland
Pick dates
30 Mar - 01 Apr $ 881.00
PDX
Portland
Alaska Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Alaska Airlines
3 STOPS
PDX
Portland
Pick dates
28 Mar - 01 Apr $ 881.00
PDX
Portland
Alaska Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Alaska Airlines
3 STOPS
PDX
Portland
Pick dates

One-way flights to Santiago from Portland

7:00 AM - 1:00 AM
Sky Airline
2 Stops
19h 40m
PDX - SCL
$ 366
Kiwi
Pick dates
7:30 AM - 8:45 PM
United Airlines
2 Stops
20h 20m
PDX - SCL
$ 574
Kiwi
Pick dates
8:30 AM - 8:45 PM
United Airlines
2 Stops
19h 20m
PDX - SCL
$ 624
Kiwi
Pick dates

How to find the cheapest flight from Portland (PDX) to Santiago (SCL)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Portland (PDX) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from Portland (PDX) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.