Earn point on your loyalty program!arrow arc left

Cheap flights from San Francisco (SFO) to Santiago (SCL)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from San Francisco (SFO) to Santiago (SCL)

How to find the cheapest flight from San Francisco (SFO) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from San Francisco to Santiago in September , October 2026

30 Sep - 03 Oct $ 1,088.00
SFO
San Francisco
Avianca
1 STOPS
SCL
Santiago
SCL
Santiago
Avianca
2 STOPS
SFO
San Francisco
Pick dates
28 Sep - 06 Oct $ 1,096.00
SFO
San Francisco
Avianca
1 STOPS
SCL
Santiago
SCL
Santiago
Avianca
2 STOPS
SFO
San Francisco
Pick dates
27 Sep - 05 Oct $ 1,501.00
SFO
San Francisco
LATAM Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
LATAM Airlines
1 STOPS
SFO
San Francisco
Pick dates

Last minute flights from San Francisco to Santiago

28 Sep - 30 Sep $ 1,096.00
SFO
San Francisco
Avianca
1 STOPS
SCL
Santiago
SCL
Santiago
Avianca
2 STOPS
SFO
San Francisco
Pick dates
28 Sep - 30 Sep $ 1,195.00
SFO
San Francisco
Avianca
2 STOPS
SCL
Santiago
SCL
Santiago
Avianca
2 STOPS
SFO
San Francisco
Pick dates
27 Sep - 01 Oct $ 1,603.00
SFO
San Francisco
LATAM Airlines
1 STOPS
SCL
Santiago
SCL
Santiago
LATAM Airlines
1 STOPS
SFO
San Francisco
Pick dates

One-way flights to Santiago from San Francisco

1:12 AM - 3:08 PM
Copa Airlines
1 Stops
18h 27m
SFO - SCL
$ 562
Kiwi
Pick dates
6:00 AM - 10:05 PM
LATAM Airlines
1 Stops
22h 15m
SFO - SCL
$ 565
Kiwi
Pick dates
11:58 AM - 2:55 PM
LATAM Airlines
1 Stops
13h 37m
SFO - SCL
$ 746
Kiwi
Pick dates

How to find the cheapest flight from San Francisco (SFO) to Santiago (SCL)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from San Francisco (SFO) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.