Earn point on your loyalty program!arrow arc left

Cheap flights from St Louis (STL) to Santiago (SCL)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from St Louis (STL) to Santiago (SCL)

How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from St Louis to Santiago in April , May 2026

27 Apr - 08 May $ 738.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates
28 Apr - 04 May $ 742.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates
25 Apr - 04 May $ 777.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates

Last minute flights from St Louis to Santiago

27 Apr - 01 May $ 818.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
3 STOPS
STL
St Louis
Pick dates
28 Apr - 01 May $ 855.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates
27 Apr - 01 May $ 855.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates

One-way flights to Santiago from St Louis

4:59 PM - 7:15 AM
Avianca
2 Stops
20h 16m
STL - SCL
$ 344
Kiwi
Pick dates
4:21 PM - 10:10 PM
LATAM Airlines
1 Stops
13h 54m
STL - SCL
$ 761
Kiwi
Pick dates
6:00 AM - 3:08 PM
United Airlines
2 Stops
15h 43m
STL - SCL
$ 782
Kiwi
Pick dates

How to find the cheapest flight from St Louis (STL) to Santiago (SCL)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.