Earn point on your loyalty program!arrow arc left

Cheap flights from St Louis (STL) to Santiago (SCL)

Know your dates, get live prices in seconds
airplane logo

pin logo

calendar
Departure
calendar backward
Return
airplane logo
1 Adults (11+)
0 Children (2~11)
0 Infants (0~2)
Save up to 31%
Book Flight + Hotel at the same time

How to find the cheapest flight from St Louis (STL) to Santiago (SCL)

How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.

Cheap flights from St Louis to Santiago in November , December 2026

25 Nov - 02 Dec $ 1,155.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates
16 Nov - 09 Dec $ 1,589.00
STL
St Louis
Air Canada
1 STOPS
SCL
Santiago
SCL
Santiago
Air Canada
1 STOPS
STL
St Louis
Pick dates
18 Nov - 02 Dec $ 1,598.00
STL
St Louis
Air Canada
1 STOPS
SCL
Santiago
SCL
Santiago
Air Canada
1 STOPS
STL
St Louis
Pick dates

Last minute flights from St Louis to Santiago

25 Nov - 01 Dec $ 1,093.00
STL
St Louis
Frontier Airlines
2 STOPS
SCL
Santiago
SCL
Santiago
Frontier Airlines
2 STOPS
STL
St Louis
Pick dates
18 Nov - 01 Dec $ 1,645.00
STL
St Louis
Air Canada
1 STOPS
SCL
Santiago
SCL
Santiago
Air Canada
1 STOPS
STL
St Louis
Pick dates
16 Nov - 01 Dec $ 1,647.00
STL
St Louis
Air Canada
1 STOPS
SCL
Santiago
SCL
Santiago
Air Canada
1 STOPS
STL
St Louis
Pick dates

One-way flights to Santiago from St Louis

6:34 PM - 3:56 PM
Copa Airlines
3 Stops
26h 50m
STL - SCL
$ 540
Kiwi
Pick dates
4:05 PM - 11:35 PM
Air Canada
1 Stops
17h 10m
STL - SCL
$ 849
Kiwi
Pick dates
4:05 PM - 11:35 PM
Air Canada
1 Stops
17h 10m
STL - SCL
$ 849
Kiwi
Pick dates

How to find the cheapest flight from St Louis (STL) to Santiago (SCL)

Related info for your journey
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.
How to find the cheapest flight from St Louis (STL) to Santiago (SCL)
Some placeholder content for the first accordion panel. This panel is shown by default, thanks to the .show class.